Epilepsy Related Work

 
Introduction

    Epilepsy is the name of a brain disorder characterized predominantly by recurrent and unpredictable interruptions of normal brain function, called epileptic seizures. According to the characteristics of seizures and clinical manifestations, it can be divided into focal epilepsy and generalized epilepsy. The etiology of epilepsy is complex and the pathological mechanism is unclear. Over the past two decades , the magnetic resonance imaging (MRI) technology and electroencephalogram (EEG) have been widely used to investigate epilepsy. An increasing number of evidence has been presented to reveal the potential illness mechanism.

     Using multimodel imaging techniques, our research group has done a lot of work to study epilepsy and obtained many excellent achievements. Our work focused on the localization of epileptic foci, the regulation effects of basal ganglia on epileptic activity and the alterations of resting-state brain networks in patients with epilepsy. Accumulated results help us to have a more comprehensive understanding about epilepsy.

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Publication
  1. Qifu Li, Cheng Luo, Tianhua Yang, Zhiping Yao, Li He, Ling Liu, Hongru Xu, Qqiyong Gong, Dezhong Yao, Dong Zhou*. EEG-fMRI study on the interictal and ictal generalized spike-wave discharges in patient with childhood absence epilepsy. Epilepsy Research.2009,87:160-168.
  2. Cheng Luo, Zhiping Yao, Qifu Li, Xu Lei, Dong Zhou, Yun Qin, Yang Xia, Yongxiu Lai, Qiyong Gong, Dezhong Yao. Imaging foci of epileptic discharges from simultaneous EEG and fMRI using the canonical HRF. Epilepsy Research.2010, 91(2-3): 133-142
  3. Cheng Luo, Zhiping Yao, Qifu Li, Xu Lei, Dong Zhou, Yun Qin, Yang Xia,Yongxiu Lai, Qiyong Gong, Dezhong Yao*. Imaging foci of epileptic discharges from simultaneous EEG and fMRI using the canonical HRF. Epilepsy Res,2010.91:133-42.
  4. Cheng Luo, Qifu Li, Yongxiu Lai, Yang Xia, Yun Qin, Wei Liao, Shasha Li, Dong Zhou, Dezhong Yao*, Qiyong Gong. Altered Functional Connectivity in Default Mode Network in Absence Epilepsy interictal duration without IED: A Resting-state fMRI Study. Human Brain Mapping.2011,32(3):438-449.
  5. Cheng Luo, Yang Xia, Qifu Li, Kaiqing Xue, Yongxiu Lai, Qiyong Gong, Dong Zhou*, Dezhong Yao*. Diffusion and volumetry abnormalities in subcortical nuclei of patients with absence seizures. Epilepsia. 2011, 52(6):1092-1099.
  6. Cheng Luo, Qifu Li, Yang Xia, Xu Lei, Kaiqing Xue, Zhiping Yao, Youxiu Lai, Wei Liao, Dong Zhou, Pedro A Valdes‐Sosa, Qiyong Gong, Dezhong Yao. Resting State Basal Ganglia Network in Idiopathic generalized epilepsy. Human Brain Mapping.2012,33: 1279-1294.
  7. Cheng Luo, Qifu Li, Yang Xia, Xu Lei, Kaiqing Xue, Zhiping Yao, Youxiu Lai, Wei Liao, Dong Zhou, Pedro A Valdes‐Sosa, Qiyong Gong, Dezhong Yao*. Resting State Basal Ganglia Network in Idiopathic generalized epilepsy. Human Brain Mapping.2012,33: 1279-1294.
  8. Tianhua Yang, Zhiwei Guo, Cheng Luo, Qifu Li, Bo Yan, Ling Liu, Qiyong Gong, Dezhong Yao, Dong Zhou*, White Matter Impairment in the Basal Ganglia-Thalamocortical Circuit of Drug-Naive Childhood Absence Epilepsy, Epilepsy Res 2012(99):267-273.
  9. Tianhua Yang, Cheng Luo, Qifu Li, Zhiwei Guo, Ling Liu, Qiyong Gong, Dezhong Yao, Dong Zhou*. Altered resting-state connectivity during interictal generalized spike-wave discharges in drug-naïve childhood absence epilepsy. Human Brain Mapping.2013,34(8):1761-1767.
  10. Cheng Luo, Tianhua Yang, Shipeng Tu, Jiayan Deng, Dongbo Liu, Qifu Li, Li Dong, Ilan Goldberg, Qiyong Gong, Dan Zhang, Dongmei An, Dong Zhou*, Dezhong Yao*, Altered Intrinsic Functional Connectivity of Salience Network in Childhood Absence Epilepsy, Journal of the Neurological Sciences. 2014, 339:189-195.
  11. Kaiqing Xue, Cheng Luo, Dan Zhang, Tianhua Yang, Jianfu Li, Diankun Gong, Long Chen, Yasser Iturria Medina, Jean Gotman, Dong Zhou, Dezhong Yao*, Diffusion Tensor Tractography RevealsDisrupted Structural Connectivity in Childhood Absence Epilepsy, Epilepsy Research. 2014,108(1):128-138
  12. Mingming Chen, Daqing Guo*, Tiebin Wang, Wei Jing, Yang Xia, Peng Xu, Cheng Luo, Pedro A Valdes-Sosa, Dezhong Yao*, Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence. PLoS Computational Biology, 2014, 10(3):e1003495.
  13. Qifu Li, Weifang Cao, Xiaoping Liao, Zhibin Chen, Tianhua Yang, Qiyong Gong, Dong Zhou*, Cheng Luo*, Dezhong Yao. Altered resting state functional network connectivity in children absence epilepsy. Journal of the neurological sciences. 2015.354(1-2):79-85
  14. Pu Wang, Cheng Luo, Li Dong, Yi Bin, Shi Ma, Dezhong Yao, Fuqiang Guo*. Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: An amplitude of low-frequency fluctuation study. J Neurol Sci, 2015.351(1-2),133-139.doi: 10.1016/j.jns.2015.03.005
  15. Cheng Luo*, Yaodan Zhang, Weifang Cao, Yi Huang, Fei Yang, Jianjun Wang, Shipeng Tu, Xiaoming Wang*, Dezhong Yao*. Altered Structural and Functional Feature of Striato-Cortical Circuit In Benign Epilepsy with Centrotemporal Spikes. International journal of neural systems, 2015: 1550027.
  16. Li Dong, Pu Wang, Yi.Bin, Jiayan Deng, Yongjie Li, Lin Chen, Cheng Luo, Dezhong Yao*. Local Multimodal Serial Analysis for Fusing EEG-fMRI: A New Method to Study Familial Cortical Myoclonic Tremor and Epilepsy. Autonomous Mental Development, IEEE Transactions on, 2015c. PP:1-1.
  17. 杨飞, 罗程, 蒋思思, 王晓明, 青少年肌阵挛癫痫脑网络的研究进展. 中华神经科杂志 48 (2015) 620-622
  18. Li Dong, Cheng Luo*, Yutian Zhu, Changyue Hou, Sisi Jiang, Pu Wang, Bharat B Biswal, Dezhong Yao. Complex discharge-affecting networks in juvenile myoclonic epilepsy: A simultaneous EEG-fMRI study. Hum Brain Mapp, 2016. 37(10), 3515-3529.
  19. Sisi Jiang, Cheng Luo*, Zhixuan Liu, Changyue Hou, Pu Wang,Li Dong, ChengqingZhong, Yongxiu Lai,Yang Xia.Dezhong Yao. Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study. Neural Plast.2016: 3547203
  20. Li Dong, Pu Wang, Rui Peng, Sisi Jiang, B Klugah-Brown, Cheng Luo*, Dezhong Yao*， Altered basal ganglia-cortical functional connections in frontal lobe epilepsy: A resting-state fMRI study. Epilepsy Research,2016(128):12-20
  21. Cheng Luo, Fei Yang, Jiayan Deng, Yaodan Zhang, Changyue Hou, Yue Huang, Weifang Cao, Jianjun Wang, Ruhui Xiao, Nanlin Zeng, Xiaoming Wang*, Dezhong Yao*, Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes. Medcine. 2016, 95(24) e3831, http://dx.doi.org/10.1097/MD.0000000000003831
  22. Li Dong, Hechun Li, Zhongqiong He, Sisi Jiang, Benjamin Klugah-Brown, Lin Chen, Pu Wang, Song Tan, Cheng Luo*, Dezhong Yao*. Altered local spontaneous activity in frontal lobe epilepsy: a resting-state functional magnetic resonance imaging study. Brain and Behavior, 2016, 0:1–8. e00555
  23. Jinan Gong, Xuebin Chang, Sisi Jiang, Benjamin Klugah-Brown, Song Tan, Dezhong Yao, Cheng. Luo. Microstructural alterations of white matter in juvenile myoclonic epilepsy. Elsevier， 2017. (Online)
  24. 贾晓燕，叶国凤，蒋思思，何忠琼，罗程，尧德中. 青少年肌阵挛癫痫的小脑半球功能连接分析[J]. 四川精神卫生. 2017, 30(1)
  25. 罗程，贾晓燕，卓丽华，曹卫芳，蒋宇超，蒋思思，尧德中.小脑 非运动功能异常的影像研究进展.四川精神卫生 [J]. 2017, 30(1)
  26. Sisi Jiang, Cheng Luo*, Jinan Gong, Rui Peng, Shuai Ma, Song Tan, Guofeng Ye, Li Dong, Dezhong Yao*. Aberrant thalamocortical connectivity in juvenile myoclonic epilepsy The international journal of neural systems, 2017 (Accepted)

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© Key Laboratory for NeuroInformation, Ministry of Education, China

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